a Record control number 000306150300004

a ISSN 0888-7543

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WR205

b Item number .G56 2012

a Personal name Coda, Alvin B.

h Medium Electronic Document

a Title Global transcriptional analysis of psoriatic skin and blood confirms known disease-associated pathways and highlights novel genomic "hot spots" for differentially expressed genes.

c Statement of responsibility, etc Alvin B. Coda, Murat Icen, Jason R. Smith, Animesh A.Sinha,

c Date of publication, distribution, etc 2012.

b Name of publisher, distributor, etc Academic Press Inc Elsevier Science,

a Place of publication, distribution, etc San Diego :

a Summary, etc There are major gaps in our knowledge regarding the exact mechanisms and genetic basis of psoriasis. To investigate the pathogenesis of psoriasis, gene expression in 10 skin (5 lesional, 5 nonlesional) and 11 blood (6 psoriatic, 5 nonpsoriatic) samples were examined using Affymetrix HG-U95A microarrays. We detected 535 (425 upregulated, 110 downregulated) DEGs in lesional skin at 1% false discovery rate (FDR). Combining nine microarray studies comparing lesional and nonlesional psoriatic skin, 34.5% of dys-regulated genes were overlapped in multiple studies. We further identified 20 skin and 2 blood associated transcriptional "hot spots" at specified genomic locations. At 5% FDR, 11.8% skin and 10.4% blood DEGs in our study mapped to one of the 12 PSORS loci. DEGs that overlap with PSORS loci may offer prioritized targets for downstream genetic fine mapping studies. Novel DEC "hot spots" may provide new targets for defining susceptibility loci in future studies. (C) 2012 Elsevier Inc. All rights reserved.

a Topical term or geographic name as entry element Psoriasis.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Biotechnology & Applied Microbiology

a Topical term or geographic name as entry element Microarrays

a Topical term or geographic name as entry element Pathogenesis

a Main entry heading Genomics

g Relationship information JUL 2012, Vol 100 Issue 1, p18-26

x International Standard Serial Number 08887543

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.ygeno.2012.05.004